Etomidate and methohexitone.

Changes in haemodynamic variables with thiopentone, methohexitone, propofol and etomidate.

Efferent vagal discharge and heart rate in response to methohexitone, althesin, ketamine and etomidate in cats.

The effects of methohexitone, Althesin, ketamine and etomidate on single fibre discharge of cardiac vagal efferents and on heart rate were studied in cats. Cardiac vagal efferents were inhibited markedly and regularly for equihypnotic doses of methohexitone (2.0 mg kg-1), Althesin (0.1 ml kg-1) and ketamine (5.0 mg kg-1), but not of etomidate (0.8 mg kg-1). These inhibitory effects were indepen...

Etomidate and treatment propensity.

1128 November 2014 To the Editor: Wagner et al.1 must be congratulated for their robust and interesting work into the effects of a single dose of etomidate on long-term outcomes. Nonetheless, we consider that several elements would benefit from greater information and discussion. First, the doses of etomidate administered were not reported and therefore any dose–response effect remains unclear;...

Divided doses of methohexitone improves ECT outcome.

To the Editor: We read with interest the recent report on substitution of mivacurium for succinylcholine for ECT treatment. ~ Since the effect of mivacurium outlasts the effect of methohexitone (MH) the authors suggested reversal of the neuromuscular block after treatment to avoid awareness. While we are unaware of a correlation between the length of seizures and the antidepressant effect of EC...

Evaluation of three preparations of etomidate.

Three formulations of etomidate were evaluated in unpremedicated patients undergoing minor gynaecological procedures. There was a high frequency of pain on injection (up to 50%) and excitatory phenomena (up to 95%) with all formulations. The frequency of excitatory phenomena was significantly greater than that after methohexitone. Recovery was rapid, but emetic sequelae were frequent and signif...